Ontology highlight
ABSTRACT:
SUBMITTER: Walsh T
PROVIDER: S-EPMC124268 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Walsh Tom T Walsh Vanessa V Vreugde Sarah S Hertzano Ronna R Shahin Hashem H Haika Smadar S Lee Ming K MK Kanaan Moien M King Mary-Claire MC Avraham Karen B KB
Proceedings of the National Academy of Sciences of the United States of America 20020501 11
Normal vision in Drosophila requires NINAC, a class III myosin. Class III myosins are hybrid motor-signaling molecules, with an N-terminal kinase domain, highly conserved head and neck domains, and a class III-specific tail domain. In Drosophila rhabdomeres, NINAC interacts with actin filaments and with a PDZ scaffolding protein to organize the phototransduction machinery into a signaling complex. Recessive null mutations in Drosophila NINAC delay termination of the photoreceptor response and le ...[more]