Ontology highlight
ABSTRACT:
SUBMITTER: Soccio RE
PROVIDER: S-EPMC124508 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Soccio Raymond E RE Adams Rachel M RM Romanowski Michael J MJ Sehayek Ephraim E Burley Stephen K SK Breslow Jan L JL
Proceedings of the National Academy of Sciences of the United States of America 20020501 10
Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet. StarD4 expression in cultured 3T3 cells was also sterol-regulated, and known sterol regulatory element binding protein (SREBP)-target genes showed coordinate regulation. The closest homologues to StarD4 were two other StAR-related lipid transfer (START) proteins named StarD5 and StarD6. StarD4, StarD5, and StarD6 are 205- to 233-aa proteins consist ...[more]