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MAOA haplotypes associated with thrombocyte-MAO activity.

ABSTRACT: The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-chromosome inactivation at this locus. It is plausible that a gene-dosage effect can provide some insight into the greater prevalence of depressed state in females than males.

SUBMITTER: Jansson M

PROVIDER: S-EPMC1249565 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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MAOA haplotypes associated with thrombocyte-MAO activity.

Jansson Mårten M McCarthy Shane S Sullivan Patrick F PF Dickman Paul P Andersson Björn B Oreland Lars L Schalling Martin M Pedersen Nancy L NL

BMC genetics 20050920

<h4>Background</h4>The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).<h4>Results</h4>Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as ...[more]

PMID: 16174289

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