Ontology highlight
ABSTRACT:
SUBMITTER: Mallick P
PROVIDER: S-EPMC124975 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Mallick Parag P Boutz Daniel R DR Eisenberg David D Yeates Todd O TO
Proceedings of the National Academy of Sciences of the United States of America 20020709 15
Disulfide bonds have only rarely been found in intracellular proteins. That pattern is consistent with the chemically reducing environment inside the cells of well-studied organisms. However, recent experiments and new calculations based on genomic data of archaea provide striking contradictions to this pattern. Our results indicate that the intracellular proteins of certain hyperthermophilic archaea, especially the crenarchaea Pyrobaculum aerophilum and Aeropyrum pernix, are rich in disulfide b ...[more]