Ontology highlight
ABSTRACT:
SUBMITTER: Trinh CH
PROVIDER: S-EPMC125010 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Trinh Chi H CH Smith David P DP Kalverda Arnout P AP Phillips Simon E V SE Radford Sheena E SE
Proceedings of the National Academy of Sciences of the United States of America 20020715 15
Dissociation of human beta-2-microglobulin (beta(2)m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein. As a consequence of renal failure, the concentration of circulating monomeric beta(2)m increases, ultimately leading to deposition of the protein into amyloid fibrils and development of the disorder, dialysis-related amyloidosis. Here we present the crystal structure of a monomeric form of human beta(2)m determined a ...[more]