Ontology highlight
ABSTRACT:
SUBMITTER: Kim MJ
PROVIDER: S-EPMC125047 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Kim Min-Jung MJ Jo Dong-Gyu DG Hong Gil-Sun GS Kim Byung Ju BJ Lai Michael M Cho Dong-Hyung DH Kim Ki-Woo KW Bandyopadhyay Arun A Hong Yeon-Mi YM Kim Do Han DH Cho Chunghee C Liu Jun O JO Snyder Solomon H SH Jung Yong-Keun YK
Proceedings of the National Academy of Sciences of the United States of America 20020711 15
Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during apoptosis cain/cabin1 is cleaved by calpain at the carboxyl terminus to generate a cleavage product with a molecular mass of 32 kDa as a necessary step leading to Cn-mediated cell death. Mouse cain/cabin1 was identified from a thymus cDNA library by an in vitro substrate-screening assay with calpain. Expo ...[more]