Ontology highlight
ABSTRACT:
SUBMITTER: Kvansakul M
PROVIDER: S-EPMC125277 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Kvansakul M M Hopf M M Ries A A Timpl R R Hohenester E E
The EMBO journal 20011001 19
Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa. Their high-affinity interaction, which is likely to contribute to BM assembly and function, is mediated by the central G2 domain in nidogen and the third immunoglobulin (IG)-like domain in perlecan, IG3. We have solved the crystal structure at 2.0 A resolution of the mouse nidogen-1 G2-perlecan IG3 complex. Perlecan IG3 belongs to the I-set of the IG superfamily and binds to the wall of the n ...[more]