Ontology highlight
ABSTRACT:
SUBMITTER: Morris ES
PROVIDER: S-EPMC1253626 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Morris Edward S ES MacDonald Kelli P A KP Rowe Vanessa V Banovic Tatjana T Kuns Rachel D RD Don Alistair L J AL Bofinger Helen M HM Burman Angela C AC Olver Stuart D SD Kienzle Norbert N Porcelli Steven A SA Pellicci Daniel G DG Godfrey Dale I DI Smyth Mark J MJ Hill Geoffrey R GR
The Journal of clinical investigation 20051013 11
NKT cells have pivotal roles in immune regulation and tumor immunosurveillance. We report that the G-CSF and FMS-like tyrosine kinase 3 ligand (Flt-3L) chimeric cytokine, progenipoietin-1, markedly expands the splenic and hepatic NKT cell population and enhances functional responses to alpha-galactosylceramide. In a murine model of allogeneic stem cell transplantation, donor NKT cells promoted host DC activation and enhanced perforin-restricted CD8+ T cell cytotoxicity against host-type antigens ...[more]