Ontology highlight
ABSTRACT:
SUBMITTER: Egloff MP
PROVIDER: S-EPMC125380 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Egloff Marie-Pierre MP Benarroch Delphine D Selisko Barbara B Romette Jean-Louis JL Canard Bruno B
The EMBO journal 20020601 11
Viruses represent an attractive system with which to study the molecular basis of mRNA capping and its relation to the RNA transcription machinery. The RNA-dependent RNA polymerase NS5 of flaviviruses presents a characteristic motif of S-adenosyl-L-methionine-dependent methyltransferases at its N-terminus, and polymerase motifs at its C-terminus. The crystal structure of an N-terminal fragment of Dengue virus type 2 NS5 is reported at 2.4 A resolution. We show that this NS5 domain includes a typ ...[more]