Ontology highlight
ABSTRACT:
SUBMITTER: Ura K
PROVIDER: S-EPMC125421 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
Ura K K Araki M M Saeki H H Masutani C C Ito T T Iwai S S Mizukoshi T T Kaneda Y Y Hanaoka F F
The EMBO journal 20010401 8
To investigate the relationship between chromatin dynamics and nucleotide excision repair (NER), we have examined the effect of chromatin structure on the formation of two major classes of UV-induced DNA lesions in reconstituted dinucleosomes. Furthermore, we have developed a model chromatin-NER system consisting of purified human NER factors and dinucleosome substrates that contain pyrimidine (6-4) pyrimidone photoproducts (6-4PPs) either at the center of the nucleosome or in the linker DNA. We ...[more]