Ontology highlight
ABSTRACT:
SUBMITTER: Coutte L
PROVIDER: S-EPMC125627 | biostudies-literature | 2001 Sep
REPOSITORIES: biostudies-literature
Coutte L L Antoine R R Drobecq H H Locht C C Jacob-Dubuisson F F
The EMBO journal 20010901 18
Proteins of Gram-negative bacteria destined to the extracellular milieu must cross the two cellular membranes and then fold at the appropriate time and place. The synthesis of a precursor may be a strategy to maintain secretion competence while preventing aggregation or premature folding (especially for large proteins). The secretion of 230 kDa filamentous haemagglutinin (FHA) of Bordetella pertussis requires the synthesis and the maturation of a 367 kDa precursor that undergoes the proteolytic ...[more]