Ontology highlight
ABSTRACT:
SUBMITTER: Saveanu C
PROVIDER: S-EPMC125736 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Saveanu C C Bienvenu D D Namane A A Gleizes P E PE Gas N N Jacquier A A Fromont-Racine M M
The EMBO journal 20011101 22
Eukaryotic ribosome maturation depends on a set of well ordered processing steps. Here we describe the functional characterization of yeast Nog2p (Ynr053cp), a highly conserved nuclear protein. Nog2p contains a putative GTP-binding site, which is essential in vivo. Kinetic and steady-state measurements of the levels of pre-rRNAs in Nog2p-depleted cells showed a defect in 5.8S and 25S maturation and a concomitant increase in the levels of both 27SB(S) and 7S(S) precursors. We found Nog2p physical ...[more]