Ontology highlight
ABSTRACT:
SUBMITTER: Akhmanova A
PROVIDER: S-EPMC1257404 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Akhmanova Anna A Mausset-Bonnefont Anne-Laure AL van Cappellen Wiggert W Keijzer Nanda N Hoogenraad Casper C CC Stepanova Tatiana T Drabek Ksenija K van der Wees Jacqueline J Mommaas Mieke M Onderwater Jos J van der Meulen Hans H Tanenbaum Marvin E ME Medema Rene H RH Hoogerbrugge Jos J Vreeburg Jan J Uringa Evert-Jan EJ Grootegoed J Anton JA Grosveld Frank F Galjart Niels N
Genes & development 20051001 20
CLIP-170 is a microtubule "plus-end-tracking protein" implicated in the control of microtubule dynamics, dynactin localization, and the linking of endosomes to microtubules. To investigate the function of mouse CLIP-170, we generated CLIP-170 knockout and GFP-CLIP-170 knock-in alleles. Residual CLIP-170 is detected in lungs and embryos of homozygous CLIP-170 knockout mice, but not in other tissues and cell types, indicating that we have generated a hypomorphic mutant. Homozygous CLIP-170 knockou ...[more]