Ontology highlight
ABSTRACT:
SUBMITTER: Pradhan S
PROVIDER: S-EPMC125847 | biostudies-literature | 2002 Feb
REPOSITORIES: biostudies-literature
Pradhan Sriharsa S Kim Gun-Do GD
The EMBO journal 20020201 4
The mammalian DNA (cytosine-5) methyltransferase (Dnmt1) is involved in the maintenance of methylation patterns in the genome during DNA replication and development. The retinoblastoma gene product, Rb, is a cell cycle regulator protein that represses transcription by recruiting histone deacetylase (HDAC1). In vivo, histone deacetylase associates with Dnmt1. Here we show that Rb itself associates with human Dnmt1 (hDnmt1) independently of its own phosphorylation status. Methyltransferase activit ...[more]