Ontology highlight
ABSTRACT:
SUBMITTER: Chiu TK
PROVIDER: S-EPMC125850 | biostudies-literature | 2002 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20020201 4
The Hin recombinase specifically recognizes its DNA-binding site by means of both major and minor groove interactions. A previous X-ray structure, together with new structures of the Hin DNA-binding domain bound to a recombination half-site that were solved as part of the present study, have revealed that two ordered water molecules are present within the major groove interface. In this report, we test the importance of these waters directly by X-ray crystal structure analysis of complexes with ...[more]