Ontology highlight
ABSTRACT:
SUBMITTER: Kalodimos CG
PROVIDER: S-EPMC126071 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Kalodimos Charalampos G CG Bonvin Alexandre M J J AM Salinas Roberto K RK Wechselberger Rainer R Boelens Rolf R Kaptein Robert R
The EMBO journal 20020601 12
The lac repressor-operator system is a model system for understanding protein-DNA interactions and allosteric mechanisms in gene regulation. Despite the wealth of biochemical data provided by extensive mutations of both repressor and operator, the specific recognition mechanism of the natural lac operators by lac repressor has remained elusive. Here we present the first high-resolution structure of a dimer of the DNA-binding domain of lac repressor bound to its natural operator 01. The global po ...[more]