Ontology highlight
ABSTRACT:
SUBMITTER: Schumacher MA
PROVIDER: S-EPMC126077 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
The EMBO journal 20020701 13
In prokaryotes, Hfq regulates translation by modulating the structure of numerous RNA molecules by binding preferentially to A/U-rich sequences. To elucidate the mechanisms of target recognition and translation regulation by Hfq, we determined the crystal structures of the Staphylococcus aureus Hfq and an Hfq-RNA complex to 1.55 and 2.71 A resolution, respectively. The structures reveal that Hfq possesses the Sm-fold previously observed only in eukaryotes and archaea. However, unlike these hepta ...[more]