Ontology highlight
ABSTRACT:
SUBMITTER: Mori H
PROVIDER: S-EPMC126155 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Mori Hidetoshi H Tomari Taizo T Koshikawa Naohiko N Kajita Masahiro M Itoh Yoshifumi Y Sato Hiroshi H Tojo Hideaki H Yana Ikuo I Seiki Motoharu M
The EMBO journal 20020801 15
Membrane-type 1 matrix metalloproteinase (MT1- MMP) localizes at the front of migrating cells and degrades the extracellular matrix barrier during cancer invasion. However, it is poorly understood how the polarized distribution of MT1-MMP at the migration front is regulated. Here, we demonstrate that MT1-MMP forms a complex with CD44H via the hemopexin-like (PEX) domain. A mutant MT1-MMP lacking the PEX domain failed to bind CD44H and did not localize at the lamellipodia. The cytoplasmic tail of ...[more]