Ontology highlight
ABSTRACT:
SUBMITTER: Rivero F
PROVIDER: S-EPMC126189 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Rivero Francisco F Illenberger Daria D Somesh Baggavalli P BP Dislich Heidrun H Adam Nicola N Meyer Ann-Kathrin AK
The EMBO journal 20020901 17
Rho GDP-dissociation inhibitors (RhoGDIs) modulate the cycling of Rho GTPases between active GTP-bound and inactive GDP-bound states. We identified two RhoGDI homologues in DICTYOSTELIUM: GDI1 shares 51-58% similarity to RhoGDIs from diverse species. GDI2 is more divergent (40-44% similarity) and lacks the N-terminal regulatory arm characteristic for RhoGDI proteins. Both are cytosolic proteins and do not relocalize upon reorganization of the actin cytoskeleton. Using a two-hybrid approach, we i ...[more]