Sequences intervening between the core packaging determinants are dispensable for maintaining the packaging potential and propagation of feline immunodeficiency virus transfer vector RNAs.
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ABSTRACT:
SUBMITTER: Mustafa F
PROVIDER: S-EPMC1262595 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
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Sequences intervening between the core packaging determinants are dispensable for maintaining the packaging potential and propagation of feline immunodeficiency virus transfer vector RNAs.
Mustafa Farah F Ghazawi Akela A Jayanth Preethi P Phillip Pretty Susan PS Ali Jahabar J Rizvi Tahir A TA
Journal of virology 20051101 21
The packaging determinants of feline immunodeficiency virus (FIV) consist of two discontinuous core regions, extending from R to approximately 150 bp of the 5' untranslated region and the first approximately 100 bp of gag. However, the role of sequences intervening between the core regions in packaging has not been clear. A mutational analysis was conducted to determine whether the intervening sequences played a role in FIV RNA packaging, using an in vivo packaging assay complemented with semiqu ...[more]
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