Atomic model of the papillomavirus capsid.
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ABSTRACT:
SUBMITTER: Modis Y
PROVIDER: S-EPMC126290 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Publications
Atomic model of the papillomavirus capsid.
Modis Yorgo Y Trus Benes L BL Harrison Stephen C SC
The EMBO journal 20020901 18
Papillomaviruses propagate in differentiating skin cells, and certain types are responsible for the onset of cervical cancer. We have combined image reconstructions from electron cryomicroscopy (cryoEM) of bovine papillomavirus at 9 A resolution with coordinates from the crystal structure of small virus-like particles of the human papillomavirus type 16 L1 protein to generate an atomic model of the virion. The overall fit of the L1 model into the cryoEM map is excellent, but residues 402-446 in ...[more]
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