Ontology highlight
ABSTRACT:
SUBMITTER: Stevaux O
PROVIDER: S-EPMC126297 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Stevaux Olivier O Dimova Dessislava D Frolov Maxim V MV Taylor-Harding Barbie B Morris Erick E Dyson Nicholas N
The EMBO journal 20020901 18
RBF1, a Drosophila pRB family homolog, is required for cell cycle arrest and the regulation of E2F-dependent transcription. Here, we describe the properties of RBF2, a second family member. RBF2 represses E2F transcription and is present at E2F-regulated promoters. Analysis of in vivo protein complexes reveals that RBF1 and RBF2 interact with different subsets of E2F proteins. dE2F1, a potent transcriptional activator, is regulated specifically by RBF1. In contrast, RBF2 binds exclusively to dE2 ...[more]