Ontology highlight
ABSTRACT:
SUBMITTER: Rampalli S
PROVIDER: S-EPMC1265755 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Rampalli Shravanti S Pavithra L L Bhatt Altaf A Kundu Tapas K TK Chattopadhyay Samit S
Molecular and cellular biology 20051001 19
Matrix attachment region binding proteins have been shown to play an important role in gene regulation by altering chromatin in a stage- and tissue-specific manner. Our previous studies report that SMAR1, a matrix-associated protein, regresses B16-F1-induced tumors in mice. Here we show SMAR1 targets the cyclin D1 promoter, a gene product whose dysregulation is attributed to breast malignancies. Our studies reveal that SMAR1 represses cyclin D1 gene expression, which can be reversed by small int ...[more]