Ontology highlight
ABSTRACT:
SUBMITTER: Orchard SS
PROVIDER: S-EPMC1265980 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Orchard Samantha S SS Goodrich-Blair Heidi H
Applied and environmental microbiology 20051001 10
Xenorhabdus nematophila is a mutualist of entomopathogenic nematodes and a pathogen of insects. To begin to examine the role of pyrimidine salvage in nutrient exchange between X. nematophila and its hosts, we identified and mutated an X. nematophila tdk homologue. X. nematophila tdk mutant strains had reduced virulence toward Manduca sexta insects and a competitive defect for nematode colonization in plate-based assays. Provision of a wild-type tdk allele in trans corrected the defects of the mu ...[more]