Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA.
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ABSTRACT:
SUBMITTER: Fett T
PROVIDER: S-EPMC1266385 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
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Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA.
Fett Thomas T Zecchinon Laurent L M LL Baise Etienne A EA Desmecht Daniel J M DJ
BMC veterinary research 20051010
<h4>Background</h4>Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2) is required for many cellular adhesive interactions during the immune response.<h4>Methods</h4>We used SMART RACE technology to obtain caprine CD11a 5'- and 3'-ends and RT-PCR to amplify the full-length CDS.<h4>Results</h4>The Capra hircus CD11a-encoding cDNA was sequenced and compared with its human, murine, rat, bovine and ovine counterparts. Despite some focal differences, it shares all the main ch ...[more]
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