Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.
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ABSTRACT:
SUBMITTER: Bacchi CJ
PROVIDER: S-EPMC127003 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
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Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.
Bacchi Cyrus J CJ Weiss Louis M LM Lane Schenella S Frydman Benjamin B Valasinas Aldonia A Reddy Venodhar V Sun Jerry S JS Marton Laurence J LJ Khan Imitiaz A IA Moretto Magali M Yarlett Nigel N Wittner Murray M
Antimicrobial agents and chemotherapy 20020101 1
Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polya ...[more]
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