Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor.
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ABSTRACT:
SUBMITTER: Rodriguez-Frade JM
PROVIDER: S-EPMC1271658 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Publications
Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor.
Rodríguez-Frade José Miguel JM del Real Gustavo G Serrano Antonio A Hernanz-Falcón Patricia P Soriano Silvia F SF Vila-Coro Antonio J AJ de Ana Ana Martín AM Lucas Pilar P Prieto Ignacio I Martínez-A Carlos C Mellado Mario M
The EMBO journal 20031211 1
The identification of chemokine receptors as HIV-1 coreceptors has focused research on developing strategies to prevent HIV-1 infection. We generated CCR2-01, a CCR2 receptor-specific monoclonal antibody that neither competes with the chemokine CCL2 for binding nor triggers signaling, but nonetheless blocks replication of monotropic (R5) and T-tropic (X4) HIV-1 strains. This effect is explained by the ability of CCR2-01 to induce oligomerization of CCR2 with the CCR5 or CXCR4 viral coreceptors. ...[more]
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