Ontology highlight
ABSTRACT:
SUBMITTER: Lewis HA
PROVIDER: S-EPMC1271750 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
The EMBO journal 20031218 2
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding cassette (ABC) transporter that functions as a chloride channel. Nucleotide-binding domain 1 (NBD1), one of two ABC domains in CFTR, also contains sites for the predominant CF-causing mutation and, potentially, for regulatory phosphorylation. We have determined crystal structures for mouse NBD1 in unliganded, ADP- and ATP-bound states, with and without phosphorylation. This NBD1 differs from typical ABC domains in havin ...[more]