Ontology highlight
ABSTRACT:
SUBMITTER: Kim M
PROVIDER: S-EPMC1271760 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Kim Minkyu M Ahn Seong-Hoon SH Krogan Nevan J NJ Greenblatt Jack F JF Buratowski Stephen S
The EMBO journal 20040122 2
To understand the factor interactions of transcribing RNA polymerase II (RNApII) in vivo, chromatin immunoprecipitations were used to map the crosslinking patterns of multiple elongation and polyadenylation factors across transcribed genes. Transcription through the polyadenylation site leads to a reduction in the levels of the Ctk1 kinase and its associated phosphorylation of the RNApII C-terminal domain. One group of elongation factors (Spt4/5, Spt6/Iws1, and Spt16/Pob3), thought to mediate tr ...[more]