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BlaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513.

ABSTRACT: Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that bla(CTX-M-2) was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.

SUBMITTER: Arduino SM

PROVIDER: S-EPMC127297 | biostudies-literature | 2002 Jul

REPOSITORIES: biostudies-literature

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blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513.

Arduino Sonia M SM Roy Paul H PH Jacoby George A GA Orman Betina E BE Pineiro Silvia A SA Centron Daniela D

Antimicrobial agents and chemotherapy 20020701 7

Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that bla(CTX-M-2) was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved. ...[more]

PMID: 12069995

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