Ontology highlight
ABSTRACT:
SUBMITTER: Nyfeler Y
PROVIDER: S-EPMC1276174 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Nyfeler Yves Y Kirch Robert D RD Mantei Ned N Leone Dino P DP Radtke Freddy F Suter Ueli U Taylor Verdon V
The EMBO journal 20050915 19
Neural stem cells (NSCs) in the postnatal mammalian brain self-renew and are a source of neurons and glia. To date, little is known about the molecular and cellular mechanisms regulating the maintenance and differentiation of these multipotent progenitors. We show that Jagged1 is required by mitotic cells in the subventricular zone (SVZ) and stimulates self-renewal of multipotent epidermal growth factor-dependent NSCs. Jagged1-expressing cells line the adult SVZ and are juxtaposed to Notch1-expr ...[more]