Unknown

Dataset Information

0

Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes.


ABSTRACT: Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeensis. We investigated the impact of two genes that control macrophage and T-cell function on murine resistance to E. chaffeensis. Congenic pairs of wild-type and toll-like receptor 4 (tlr4)- or major histocompatibility complex class II (MHC-II)-deficient mice were used for these studies. Wild-type mice cleared the infection within 2 weeks, and the response included macrophage activation and the synthesis of E. chaffeensis-specific Th1-type immunoglobulin G response. The absence of a functional tlr4 gene depressed nitric oxide and interleukin 6 secretion by macrophages and resulted in short-term persistent infections for > or =30 days. In the absence of MHC-II alleles, E. chaffeensis infections persisted throughout the entire 3-month evaluation period. Together, these data suggest that macrophage activation and cell-mediated immunity, orchestrated by CD4(+) T cells, are critical for conferring resistance to E. chaffeensis.

SUBMITTER: Ganta RR 

PROVIDER: S-EPMC127650 | biostudies-literature | 2002 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes.

Ganta Roman Reddy RR   Wilkerson Melinda J MJ   Cheng Chuanmin C   Rokey Aaron M AM   Chapes Stephen K SK  

Infection and immunity 20020101 1


Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeensis. We investigated the impact of two genes that control macrophage and T-cell function on murine resistance to E. chaffeensis. Congenic pairs of wild-type and toll-like receptor 4 (tlr4)- or major histocompatibility complex class II (MHC-II)-deficient mice were used for these studies. Wild-type mice cleared the infection within 2 weeks, and the response included macrophage activation and t  ...[more]

Similar Datasets

| PRJNA862637 | ENA
| S-EPMC6459222 | biostudies-literature
| S-EPMC3639783 | biostudies-literature
| S-EPMC50662 | biostudies-other
| S-EPMC18298 | biostudies-literature
2017-03-15 | GSE90474 | GEO
| S-EPMC4198495 | biostudies-literature
| S-EPMC3162010 | biostudies-literature
| S-EPMC10904449 | biostudies-literature
| S-EPMC5471237 | biostudies-literature