Ontology highlight
ABSTRACT:
SUBMITTER: Komori H
PROVIDER: S-EPMC1276720 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Komori Hideyuki H Enomoto Mitsuru M Nakamura Masataka M Iwanaga Ritsuko R Ohtani Kiyoshi K
The EMBO journal 20051006 21
The tumor suppressor p14(ARF) gene is induced by ectopically expressed E2F, a positive regulator of the cell cycle. The gene is expressed at low levels in normally growing cells in contrast to high levels in varieties of tumors. How p14(ARF) gene is regulated by E2F in normally growing cells and tumor cells remains obscure. Here we show that regulation of p14(ARF) gene by E2F is distinct from that of classical E2F targets. It is directly mediated by E2F through a novel E2F-responsive element tha ...[more]