Unknown

Dataset Information

0

Fibronectin attachment protein is necessary for efficient attachment and invasion of epithelial cells by Mycobacterium avium subsp. paratuberculosis.


ABSTRACT: Attachment and ingestion of Mycobacterium avium subsp. paratuberculosis by two epithelial cell lines were enhanced by soluble fibronectin (FN). Peptide blocking of the FN attachment protein (FAP-P) inhibited the internalization of M. avium subsp. paratuberculosis. Disruption of FAP-P expression significantly reduced attachment and ingestion of M. avium subsp. paratuberculosis by T-24 and Caco-2 cells. The results indicate that the interaction between FN and FAP-P facilitates attachment and internalization of M. avium subsp. paratuberculosis by epithelial cells.

SUBMITTER: Secott TE 

PROVIDER: S-EPMC127902 | biostudies-literature | 2002 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Fibronectin attachment protein is necessary for efficient attachment and invasion of epithelial cells by Mycobacterium avium subsp. paratuberculosis.

Secott T E TE   Lin T L TL   Wu C C CC  

Infection and immunity 20020501 5


Attachment and ingestion of Mycobacterium avium subsp. paratuberculosis by two epithelial cell lines were enhanced by soluble fibronectin (FN). Peptide blocking of the FN attachment protein (FAP-P) inhibited the internalization of M. avium subsp. paratuberculosis. Disruption of FAP-P expression significantly reduced attachment and ingestion of M. avium subsp. paratuberculosis by T-24 and Caco-2 cells. The results indicate that the interaction between FN and FAP-P facilitates attachment and inter  ...[more]

Similar Datasets

| S-EPMC98132 | biostudies-literature
| S-EPMC427427 | biostudies-literature
| S-EPMC3366327 | biostudies-literature
| S-EPMC4810606 | biostudies-literature
| S-EPMC88986 | biostudies-literature
| S-EPMC140397 | biostudies-literature
| S-EPMC156888 | biostudies-literature
| S-EPMC1234005 | biostudies-literature
| S-EPMC3675962 | biostudies-literature
2016-03-01 | GSE71291 | GEO