Identification and functional analysis of an immunoreactive DsbA-like thio-disulfide oxidoreductase of Ehrlichia spp.
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ABSTRACT:
SUBMITTER: McBride JW
PROVIDER: S-EPMC127935 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Publications
Identification and functional analysis of an immunoreactive DsbA-like thio-disulfide oxidoreductase of Ehrlichia spp.
McBride Jere W JW Ndip Lucy M LM Popov Vsevolod L VL Walker David H DH
Infection and immunity 20020501 5
Novel homologous DsbA-like disulfide bond formation (Dsb) proteins of Ehrlichia chaffeensis and Ehrlichia canis were identified which restored DsbA activity in complemented Escherichia coli dsbA mutants. Recombinant Ehrlichia Dsb (eDsb) proteins were recognized by sera from E. canis-infected dogs but not from E. chaffeensis-infected patients. The eDsb proteins were observed primarily in the periplasm of E. chaffeensis and E. canis. ...[more]
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