Yersinia pseudotuberculosis produces a cytotoxic necrotizing factor.
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ABSTRACT:
SUBMITTER: Lockman HA
PROVIDER: S-EPMC127951 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
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Yersinia pseudotuberculosis produces a cytotoxic necrotizing factor.
Lockman Hank A HA Gillespie Rebecca A RA Baker Beth D BD Shakhnovich Elizabeth E
Infection and immunity 20020501 5
Cell extracts from Yersinia pseudotuberculosis induced multinucleation in HEp-2 cells in a manner similar to the effect caused by Escherichia coli cytotoxic necrotizing factor (CNF). The activity was not dependent on the Yersinia 70-kb virulence plasmid, and the activity was not inhibited by antibodies capable of neutralizing E. coli CNF type 1. The nucleotide sequence of the Yersinia cnf gene was 65.1% identical to the E. coli cnf gene. ...[more]
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