Ontology highlight
ABSTRACT:
SUBMITTER: Nishikawa M
PROVIDER: S-EPMC1280122 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Nishikawa Masao M Takashima Katsunori K Nishi Toshiya T Furuta Rika A RA Kanzaki Naoyuki N Yamamoto Yoshio Y Fujisawa Jun-Ichi J
Antimicrobial agents and chemotherapy 20051101 11
G protein-coupled receptor CCR5 is the main coreceptor for macrophage-tropic human immunodeficiency virus type 1 (HIV-1), and various small-molecule CCR5 antagonists are being developed to treat HIV-1 infection. It has been reported that such CCR5 antagonists, including TAK-779, bind to a putative binding pocket formed by transmembrane domains (TMs) 1, 2, 3 and 7 of CCR5, indicating the importance of the conformational changes of the TMs during virus entry. In this report, using a single-round i ...[more]