Recombination between the dfrA12-orfF-aadA2 cassette array and an aadA1 gene cassette creates a hybrid cassette, aadA8b.
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ABSTRACT:
SUBMITTER: Gestal AM
PROVIDER: S-EPMC1280176 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Publications
Recombination between the dfrA12-orfF-aadA2 cassette array and an aadA1 gene cassette creates a hybrid cassette, aadA8b.
Gestal Alicia M AM Stokes H W HW Partridge Sally R SR Hall Ruth M RM
Antimicrobial agents and chemotherapy 20051101 11
Homologous recombination between closely related gene cassettes, such as aadA1 and aadA2, which are 89% identical, can create hybrid cassettes and hybrids of existing cassette arrays. A new cassette array, dfrA12-orfF-aadA8b, which was created by such a recombination event occurring within the aadA2 cassette in the dfrA12-orfF-aadA2 array, has been identified. ...[more]
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