Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor.
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ABSTRACT:
SUBMITTER: de Haan CA
PROVIDER: S-EPMC1280238 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Publications
Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor.
de Haan Cornelis A M CA Li Zhen Z te Lintelo Eddie E Bosch Berend Jan BJ Haijema Bert Jan BJ Rottier Peter J M PJ
Journal of virology 20051101 22
Only a relatively few mutations in its spike protein allow the murine coronavirus to switch from a murine-restricted tropism to an extended host range by being passaged in vitro. One such virus that we studied had acquired two putative heparan sulfate-binding sites while preserving another site in the furin-cleavage motif. The adaptation of the virus through the use of heparan sulfate as an attachment/entry receptor was demonstrated by increased heparin binding as well as by inhibition of infect ...[more]
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