Ontology highlight
ABSTRACT:
SUBMITTER: Katae M
PROVIDER: S-EPMC128276 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Katae Masaharu M Miyahira Yasushi Y Takeda Kazuyoshi K Matsuda Hironori H Yagita Hideo H Okumura Ko K Takeuchi Tsutomu T Kamiyama Tsuneo T Ohwada Akihiko A Fukuchi Yoshinosuke Y Aoki Takashi T
Infection and immunity 20020901 9
We tested the immunogenicity of two Trypanosoma cruzi antigens injected into mice in the form of DNA vaccine. Immunization with DNA encoding dihydroorotate dehydrogenase did not confer protective immunity in all mouse strains tested. Immunization with DNA encoding trans-sialidase surface antigen (TSSA) protected C57BL/6 (H-2(b)) mice but not BALB/c (H-2(d)) or C3H/Hej (H-2(k)) mice against lethal T. cruzi infection. In vivo depletion of CD4(+) or CD8(+) T cells abolished the protective immunity ...[more]