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Genes that mediate breast cancer metastasis to lung.

ABSTRACT: By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

SUBMITTER: Minn AJ

PROVIDER: S-EPMC1283098 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature

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Genes that mediate breast cancer metastasis to lung.

Minn Andy J AJ Gupta Gaorav P GP Siegel Peter M PM Bos Paula D PD Shu Weiping W Giri Dilip D DD Viale Agnes A Olshen Adam B AB Gerald William L WL Massagué Joan J

Nature 20050701 7050

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis. ...[more]

PMID: 16049480

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