Ontology highlight
ABSTRACT:
SUBMITTER: Cohn DH
PROVIDER: S-EPMC1287524 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
American journal of human genetics 20000804 3
Linkage studies were performed in a large family with an autosomal dominant phenotype characterized by nephropathy and hypertension. In this family of Iraqi Jewish origin, the nephropathy develops into progressive renal failure. By performing a genomewide linkage search, we localized the disease gene to chromosome 1q21; the highest LOD score was obtained for the marker at locus D1S305, which yielded a maximum LOD score of 4.71 at a recombination fraction of 0. Recombination mapping defined an in ...[more]