Ontology highlight
ABSTRACT:
SUBMITTER: Ribeiro IP
PROVIDER: S-EPMC1287578 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Ribeiro Ieda P IP Menezes Albert N AN Moreira Miguel A M MA Bonvicino Cibele R CR Seuánez Héctor N HN Soares Marcelo A MA
Journal of virology 20051201 23
Host cell factors modulate retroviral infections. Among those, cyclophilin A (CypA) promotes virus infectivity by facilitating virus uncoating or capsid unfolding or by preventing retroviral capsid interaction with cellular restriction factors. In Aotus species, a retrotransposed copy of CypA inserted into the tripartite motif 5 (TRIM5) gene encodes a fusion protein which may block human immunodeficiency virus type 1 by targeting the incoming virus to ubiquitin-ligated degradation or by interfer ...[more]