Ontology highlight
ABSTRACT:
SUBMITTER: Jung M
PROVIDER: S-EPMC1288240 | biostudies-literature | 1999 Oct
REPOSITORIES: biostudies-literature
American journal of human genetics 19991001 4
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most frequent indication for heart transplantation in young patients. Probably >25% of DCM cases are of familial etiology. We report here genetic localization in a three-generation German family with 12 affected individuals with autosomal dominant familial DCM characterized by ventricular dilatation, impaired systolic function, and conduction disease. After exclusion of known DCM loci, we performed a whole-genome screen and ...[more]