Ontology highlight
ABSTRACT:
SUBMITTER: Friddle C
PROVIDER: S-EPMC1288327 | biostudies-literature | 2000 Jan
REPOSITORIES: biostudies-literature
Friddle C C Koskela R R Ranade K K Hebert J J Cargill M M Clark C D CD McInnis M M Simpson S S McMahon F F Stine O C OC Meyers D D Xu J J MacKinnon D D Swift-Scanlan T T Jamison K K Folstein S S Daly M M Kruglyak L L Marr T T DePaulo J R JR Botstein D D
American journal of human genetics 20000101 1
A genome scan of approximately 12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the ...[more]