Clustered 11q23 and 22q11 breakpoints and 3:1 meiotic malsegregation in multiple unrelated t(11;22) families.
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ABSTRACT:
SUBMITTER: Shaikh TH
PROVIDER: S-EPMC1288370 | biostudies-literature | 1999 Dec
REPOSITORIES: biostudies-literature
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Clustered 11q23 and 22q11 breakpoints and 3:1 meiotic malsegregation in multiple unrelated t(11;22) families.
Shaikh T H TH Budarf M L ML Celle L L Zackai E H EH Emanuel B S BS
American journal of human genetics 19991201 6
The t(11;22) is the only known recurrent, non-Robertsonian constitutional translocation. We have analyzed t(11;22) balanced-translocation carriers from multiple unrelated families by FISH, to localize the t(11;22) breakpoints on both chromosome 11 and chromosome 22. In 23 unrelated balanced-translocation carriers, the breakpoint was localized within a 400-kb interval between D22S788 (N41) and ZNF74, on 22q11. Also, 13 of these 23 carriers were tested with probes from chromosome 11, and, in each, ...[more]
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