A general conditional-logistic model for affected-relative-pair linkage studies.
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ABSTRACT:
SUBMITTER: Olson JM
PROVIDER: S-EPMC1288403 | biostudies-literature | 1999 Dec
REPOSITORIES: biostudies-literature
Publications
A general conditional-logistic model for affected-relative-pair linkage studies.
American journal of human genetics 19991201 6
Model-free LOD-score methods are often employed to detect linkage between marker loci and common diseases, with samples of affected sib pairs. Although extensions of the basic one-disease-locus model have been proposed that allow separate inclusion of other types of affected relative pairs, discordant relative pairs, covariates, or additional disease loci, a unified framework that can handle all of these features has been lacking. In this report, I propose a conditional-logistic parameterization ...[more]
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