Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.
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ABSTRACT:
SUBMITTER: Hiroi N
PROVIDER: S-EPMC129043 | biostudies-literature | 2002 Oct
REPOSITORIES: biostudies-literature
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Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.
Hiroi Noriko N Ito Takaaki T Yamamoto Hanako H Ochiya Takahiro T Jinno Shigeki S Okayama Hiroto H
The EMBO journal 20021001 19
Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via for ...[more]
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