Ontology highlight
ABSTRACT:
SUBMITTER: Svitkin YV
PROVIDER: S-EPMC1291233 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Svitkin Yuri V YV Herdy Barbara B Costa-Mattioli Mauro M Gingras Anne-Claude AC Raught Brian B Sonenberg Nahum N
Molecular and cellular biology 20051201 23
Translation of m7G-capped cellular mRNAs is initiated by recruitment of ribosomes to the 5' end of mRNAs via eukaryotic translation initiation factor 4F (eIF4F), a heterotrimeric complex comprised of a cap-binding subunit (eIF4E) and an RNA helicase (eIF4A) bridged by a scaffolding molecule (eIF4G). Internal translation initiation bypasses the requirement for the cap and eIF4E and occurs on viral and cellular mRNAs containing internal ribosomal entry sites (IRESs). Here we demonstrate that eIF4E ...[more]