Ontology highlight
ABSTRACT:
SUBMITTER: Cheng WC
PROVIDER: S-EPMC1291267 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Cheng Wen-Chi WC Chang Yu-Ning YN Wang Wen-Ching WC
Journal of bacteriology 20051201 23
Shikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in the shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development of new antimicrobial agents, herbicides, and antiparasitic agents. Here, we report the 1.8-Angstroms crystal structure of Helicobacter pylori shikimate kinase (HpS ...[more]